top 学院网站中文 English
姓名:尹大志
联系电话:021-62233286
电子邮箱:dzyin@psy.ecnu.edu.cn
通讯地址:上海市普陀区中山北路3663号华东师范大学老图书馆302室
研究方向:脑功能成像与网络神经科学
个人简介

个人简介:

尹大志,博士,现任华东师范大学心理与认知科学学院紫江青年研究员。

2014年6月毕业于华东师范大学物理系上海市磁共振重点实验室,获得理学博士学位。博士期间(2012年9月至2014年5月),在美国哥伦比亚大学精神病学系进行博士生联合培养(国家留学基金委公派)。2014年8月至2019年9月,在中国科学院神经科学研究所脑影像中心依次担任助理研究员、副研究员。2017年入选“中国科学院青年创新促进会”,2018年获得“长三角神经科学青年科学家奖”和“赛诺菲-中国科学院上海生命科学研究院”优秀青年人才奖励基金。主要从事功能磁共振成像技术在脑认知和脑疾病中的应用研究,特别关注静息态脑功能网络的计算方法学。相关研究成果已发表在Biological Psychiatry、Journal of Neuroscience、JCEM、Human Brain Mapping等国际主流学术期刊上。

 

研究兴趣:

1.  科学问题:自发(内在)脑活动组织规律,认知/行为灵活性的神经基础,脑可塑性,重大神经精神疾病的诊疗机制。

2.  研究方法:多模态磁共振成像技术,神经调控与干预,复杂网络,动态脑网络,图论,复杂性。

 

主持/参与科研项目情况:

1.  国家自然科学基金青年项目,“静息态功能连接模式的动态重配及其应用研究”,31600869,2017/1-2019/12,20万元(主持)

2.  中国科学院青年创新促进会资助基金,SIBS-10-5,2018/1-2021/12,80万元(20万/年)(主持)

3.  中国科学院上海生命科学研究院优秀青年人才领域前沿项目, “一种联合多模态磁共振成像方法预测脑中风患者手功能转归”,2014KIP206,2014/10-2016/9,15万元(主持)

4. 科技部重点研发计划,“甲基苯丙胺依赖诊断与复发预警客观指标和干预新技术体系的研发”,2017YFC1310400,2017/07 -2020/12, 785万元(骨干成员)

 

已发表学术论文(#第一作者,*通讯作者)

1.  Yin D, Chen X, Zeljic K, Zhan Y, Shen X, Yan G, and Wang Z. A Graph Representation of Functional Diversity of Brain Regions. Brain and Behavior. 2019; e01358.

2.  Fang F, Lai M, Huang J, Kang M, Ma M, Li K, Lian J, Wang Z, Yin D*, Wang Y*. Compensatory Hippocampal Connectivity in Young Adults with Early-Stage Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism. 2019; 104:3025–3038.

3.  Yin D, Zhang Z, Wang Z, Zeljic K, Lv Q, Cai D, Wang Y, Wang Z. Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans. Frontiers in Neuroscience. 2019, 13:174.

4.  Li HF#, Yang L#, Yin D#, Chen WJ, Liu GL, Ni W, Wang N, Yu W, Wu ZY, Wang Z. Associations between neuroanatomical abnormality and motor symptoms in paroxysmal kinesigenic dyskinesia. Parkinsonism & Related Disorders. 2019; 62:134-140

5.  Yin D#, Zhang C#, Lv Q, Chen X, Zeljic K, Gong H, Zhan S, Jin H, Wang Z, Sun B. Dissociable Frontostriatal Connectivity: Mechanism and Predictor of the Clinical Efficacy of Capsulotomy in Obsessive-Compulsive Disorder. Biological Psychiatry. 2018; 84:926-936. [Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry, 2018, 84(12): e85-e87]

6.  Zhao Z, Wu J, Fan M, Yin D, Tang C, Gong J, Xu G, Gao X, Yu Q, Yang H, Sun L, Jia J. Altered intra- and inter-network functional coupling of resting-state networks associated with motor dysfunction in stroke. Human Brain Mapping. 2018; 39:3388-3397.

7.  Zhao Z, Tang C, Yin D, Wu J, Gong J, Sun L, Jia J, Xu D, Fan M. Frequency-specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function. Human Brain Mapping. 2018; 39:4373-4384.

8.  Zou Y, Zhao Z, Yin D, Fan M, Small M, Liu Z, Hilgetag CC, Kurths J. Brain anomaly networks uncover heterogeneous functional reorganization patterns after stroke. Neuroimage Clinical. 2018; 20:523-530.

9.  Peng W, Mao L, Yin D, Sun W, Wang H, Zhang Q, Wang J, Chen C, Zeng M, Ding J, Wang X. Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy. Seizure. 2018; 60:16-22.

10. Fang F, Zhan Y, Zhuo Y, Yin D, Li K, Wang Y. Brain atrophy in middle-aged subjects with Type 2 diabetes mellitus, with and without microvascular complications. Journal of Diabetes. 2018; 10:625-632.

11. Song Y, Li W, Meng S, Zhou W, Su B, Tang L, Zhao Y, Wu X, Yin D, Fan M, Zhou C. Dual integrin alphavbeta 3 and NRP-1-Targeting Paramagnetic Liposome for Tumor Early Detection in Magnetic Resonance Imaging. Nanoscale Research Letters. 2018; 13:380.

12. Yin D#, Liu W#, Zeljic K, Lv Q, Wang Z, You M, Men W, Fan M, Cheng W, Wang Z. Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder. Scientific Reports. 2017; 7:6583.

13. Wen Z, Cheng , Yin D, Sun S, Wang Z, Yu S, Zhang Y, Qiu Z, Du Y. Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing. Neuroscience Bulletin. 2017; 33:251-254.

14. Yin D, Liu W, Zeljic K, Wang Z, Lv Q, Fan M, Cheng W, Wang Z. Dissociable Changes of Frontal and Parietal Cortices in Inherent Functional Flexibility across the Human Life Span. Journal of Neuroscience. 2016; 36(39):10060 –10074.

15. Zheng X, Sun L, Yin D, Jia J, Zhao Z, Jiang Y, Wang X, Wu J, Gong J, Fan M. The plasticity of intrinsic functional connectivity patterns associated with rehabilitation intervention in chronic stroke patients. Neuroradiology. 2016; 58:417-427.

16. Zhao Z, Wang X, Fan M, Yin D, Sun L, Jia J, Tang C, Zheng X, Jiang Y, Wu J, Gong J. Altered Effective Connectivity of the Primary Motor Cortex in Stroke: A Resting-State fMRI Study with Granger Causality Analysis. PLoS One. 2016; 11:e0166210.

17. Yan C, Su L, Wang Y, Xu T, Yin D, Fan M, Deng C, Hu Y, Wang Z, Cheung E, Lim K, Chan R. Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex. Scientific Reports. 2016; 6:29079.

18. Yan C, Wang Y, Su L, Xu T, Yin D, Fan M, Deng C, Wang Z, Lui S, Cheung E, Chan R. Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy. Psychiatry Research: Neuroimaging. 2016; 254:127-136.

19. Liu W#, Yin D#, Cheng W, Fan M, You M, Men W, Zang L, Shi D, Zhang F. Abnormal Functional Connectivity of the Amygdala-Based Network in Resting-State fMRI in Adolescents with Generalized Anxiety Disorder. Medical Science Monitor. 2015; 21: 459-467.

20. Jiang Y, Yin D, Xu D, Men W, Cao R, Li B, Fan M. Investigating microbleeding in cerebral ischemia rats using susceptibility-weighted imaging. Magnetic Resonance Imaging. 2015; 33:102-109.

21. Wang Y, Yan C, Yin D, Fan M, Cheung E, Pantelis C, Chan RC. Neurobiological changes of schizotypy: evidence from both volume-based morphometric analysis and resting-state functional connectivity. Schizophrenia Bulletin. 2015; 41 Suppl 2:S444-454.

22. Yin D, Song F, Xu D, Sun L, Men W, Zang L, Yan X, Fan M. Altered topological properties of the cortical motor-related network in patients with subcortical stroke revealed by graph theoretical analysis. Human Brain Mapping. 2014; 35:3343–3359.

23. He X, Liu W, Li X, Li Q, Liu F, Rauh VA, Yin D, Bansal R, Duan Y, Kangarlu A, Peterson BS, Xu D. Automated assessment of the quality of diffusion tensor imaging data using color cast of color-encoded fractional anisotropy images. Magnetic Resonance Imaging. 2014;32:446-456.

24. Guo W, Li D, Zhu J, Wei X, Men W, Yin D, Fan M, Xu Y. A magnetic nanoparticle stabilized gas containing emulsion for multimodal imaging and triggered drug release. Pharmaceutical Research. 2014; 31:1477–1484.

25. Lin Z, Tao J, Gao Y, Yin D, Chen A, Chen L. Analysis of central mechanism of cognitive training on cognitive impairment after stroke: Resting-state functional magnetic resonance imaging study. Journal of International Medical Research. 2014; 42(3) 659–668.

26. Yin D, Yan X, Fan M, Hu Y, Men W, Sun L, Song F. Secondary degeneration detected by combining voxel-based morphometry and tract-based spatial statistics in subcortical strokes with different outcomes in hand function. American Journal of Neuroradiology. 2013; 34:1341-1347.

27. Yin D#, Luo Y#, Song F, Xu D, Peterson BS, Sun L, Men W, Yan X, Fan M. Functional reorganization associated with outcome in hand function after stroke revealed by regional homogeneity. Neuroradiology. 2013; 55:761-770.

28. Dai H, Yin D, Hu C, Morelli JN, Hu S, Yan X, Xu D. Whole-brain voxel-based analysis of diffusion tensor mri parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage. Neuroradiology. 2013; 55:233-243.

29. Sun L, Yin D, Zhu Y, Fan M, Zang L, Wu Y, Jia J, Bai Y, Zhu B, Hu Y. Cortical reorganization after motor imagery training in chronic stroke patients with severe motor impairment: A longitudinal fmri study. Neuroradiology. 2013; 55:913-925.

30. Dai H, Morelli JN, Ai F, Yin D, Hu C, Xu D, Li Y. Resting-state functional mri: Functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients. Human Brain Mapping. 2013; 34:2455-2463.

31. Yan X, Zhou M, Ying L, Yin D, Fan M, Yang G, Zhou Y, Song F, Xu D. Evaluation of optimized b-value sampling schemas for diffusion kurtosis imaging with an application to stroke patient data. Computerized Medical Imaging and Graphics. 2013; 37:272-280.

32. Men W, Falk D, Sun T, Chen W, Li J, Yin D, Zang L, Fan M. The corpus callosum of albert einstein's brain: Another clue to his high intelligence? Brain. 2013. doi:10.1093/brain/awt252.

33. Yin D, Song F, Xu D, Peterson BS, Sun L, Men W, Yan X, Fan M. Patterns in cortical connectivity for determining outcomes in hand function after subcortical stroke. PLoS One. 2012; 7:e52727.

34. Song F#, Zhang F#, Yin D#, Hu Y, Fan M, Ni H, Nan X, Cui X, Zhou C, Huang C, Zhao Q, Ma L, Xu Y, Xia Q. Diffusion tensor imaging for predicting hand motor outcome in chronic stroke patients. Journal of International Medical Research. 2012; 40:126-133.

35. 邵方方,尹大志,贾杰,赵智勇,王想敏,郑晓慧,宋凡,范明霞,孙莉敏,皮质下脑卒中对运动想象有关脑区功能连接的影响,中国康复医学杂志,2016年第2期133-139

36. 王想敏,赵智勇,尹大志,孙莉敏,郑晓慧,贾杰,范明霞,脑卒中静息态下脑活动异常的比率低频振幅,磁共振成像,2016年第7卷第6期401-406

37. 孙莉敏,吴毅,尹大志,范明霞,臧丽丽,胡永善,健康成人在手部主动、被动和想象握拳运动时脑区激活特点的功能性磁共振成像研究,中华物理医学与康复杂志,2016年第2期126-131

38. 孙莉敏,吴毅,尹大志,范明霞,臧丽丽,胡永善,朱秉,徐一鸣,运动想象训练促进脑卒中患者上肢运动功能恢复的功能磁共振研究,中国康复医学杂志,2015年第12期 1217-1222

39. 范亮艳,范晓芳,罗位超,吴功航,严 序,尹大志,吕 岳,朱君明,徐冬溶,艺术设计中创造性思维的fMRI 研究:一项基于智能 CAD 的探索,心理学报,2014年第46卷第4期

40. 宋凡,尹大志,胡永善,范明霞,倪欢欢,崔晓,基于体素的形态学测量分析脑卒中后残障手的机制,中国康复医学杂志,2013年第28卷第7期

41. 尤美娜,程文红,门卫伟,范明霞,刘文敬,尹大志,青少年广泛性焦虑障碍患者静息态功能磁共振成像研究,临床精神医学杂志,2012年第22 卷第5 期

 

copyright©| 2012 华东师范大学心理与认知科学学院
中山北路3663号 200062 技术支持:维程互联